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Misophonia vs Hyperacusis fMRI: 91 Adults Show Different Brain Networks

Photoreal illustration of brain regions responding to sound waves with overlapping but distinct activation maps, conveying two sound-sensitivity disorder profiles.

A 2026 task-based fMRI study of 91 young adults separated misophonia from hyperacusis inside the same “sound sensitivity” experiment: misophonia-containing groups showed visual association cortex and ACC-visual network changes during unpleasant sounds, while key hyperacusis contrasts showed weaker salience-control connectivity than misophonia.1 The scan data support separating trigger-specific sound aversion from loudness-driven sound intolerance, while …

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