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cognition

Genetics & Age-Related Cognitive Decline: Insights from TOMORROW Trial (2024 Study)

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In a study utilizing data from the TOMMORROW trial, researchers have embarked on a novel exploration of genetic associations with cognitive change in older individuals. Employing a genome-wide association study (GWAS) approach, they’ve identified specific genetic variants linked to cognitive dynamics, providing new insights into the genetic underpinnings of cognitive change with aging. Highlights: Novel …

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CE-123 vs. R-Modafinil for Cognition: Dopamine Modulators (2023 Study)

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Recent advancements in neuropharmacology have brought to light S-CE-123, a dopamine transporter inhibitor showing remarkable promise in cognitive enhancement. Its emergence alongside R-modafinil, a well-studied compound with a similar target, paves the way for a fascinating comparative study. This duo of compounds, entwined in the complex dance of brain chemistry, offers a glimpse into the …

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Aesthetic Chills to Treat Depression? Psychogenic Shivers, Frisson, Goosebumps (2024 Study)

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Depression, a prevalent mental health issue, often resists traditional treatments, making innovative approaches necessary. Recent research suggests that ‘aesthetic chills’—a peak emotional response accompanied by physical sensations like goosebumps—might offer significant benefits in treating depression. Highlights: Prevalence of Depression: Over 300 million people worldwide suffer from depression, making it a critical global health concern. Limitations …

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Insulin & Blood Sugar vs. Cognitive Function & Psychiatric Disorders (2023 Evidence)

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Hyperglycemia, or high blood sugar, is more than a mere symptom of diabetes; it’s a complex condition that may significantly impact cognitive functions like memory and attention. While the association between diabetes and physical health complications is well known, there’s a growing body of research exploring how altered insulin signaling, a key feature of diabetes, …

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Effects of Pramipexole on Reward Learning: Possible Depression Treatment? (2023 Study)

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In a significant stride toward understanding and treating depression, a 2023 study meticulously investigates the effects of pramipexole, a dopamine D2-like agonist, on reward learning. By exploring its impact on healthy volunteers through rigorous behavioral and neural assessments, the research offers groundbreaking insights into how this drug (occasionally used in depression) could revolutionize therapeutic strategies …

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Microplastics & Nanoplastics Cross Blood-Brain Barrier within Hours & May Cause Damage

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Microplastics and nanoplastics (MNPs) from the breakdown of plastic materials pollute the environment and make their way into the human body, raising concerns over potential health impacts. Research shows that microplastics and nanoplastics are able to cross the blood-brain barrier in mice within 2 hours of ingestion. Key Facts: Polystyrene nanoparticles with a size of …

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Effects of Spaceflight on Astronauts’ Mental Health: Neuroplasticity Changes & Cognitive Decline

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The extreme environment of spaceflight induces a myriad of stresses on astronauts – and these stresses may negatively impact mental health, neuroplasticity, and cognitive abilities. New research offers insight into the neurological mechanisms underlying these effects. Key Facts: Prolonged spaceflight can lead to depression, anxiety, and cognitive decline in astronauts. The composite stresses of the …

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