A 2026 medRxiv preprint did not find one simple autism excitation-inhibition signature. Bertelsen et al. found 2 EEG-derived E:I neurosubtypes in 286 autistic males: a 47% inhibition-dominant subtype with higher Hurst exponent and lower gamma, and a 53% excitation-dominant subtype with the opposite pattern.1 Research Highlights Two subtypes, opposite directions: in 286 autistic males ages …
A 2026 RNA-seq analysis of 1,711 autistic probands found 3 gene-expression clusters: 425 people with more severe restricted and repetitive behaviors than the other clusters, 282 with milder symptoms and better adaptive function than the other clusters, and 1,004 with stronger social-communication impairment than the other clusters.1 The supported claim is molecular stratification, not a …
Parkinson’s disease has a years-to-decades prodromal stage where motor symptoms haven’t yet emerged but pathology is accumulating. A 2026 review by Schaeffer et al. synthesizes the case for (and limits of) intervening during this window — with implications for high-risk individuals weighing whether to enter preventive trials.1 Research Highlights Prodromal Parkinson’s disease is the period …
In the intricate puzzle of autism spectrum disorders (ASD), emerging research highlights a fascinating piece: the role of adiponectin, an anti-inflammatory adipokine, in the development and severity of ASD in children. With the backdrop of increasing ASD prevalence and the quest for biomarkers for early identification, the exploration of adiponectin offers a promising avenue for …
Bipolar Disorder (BD), a complex psychiatric condition, is under constant study to better understand its pathophysiology and improve diagnostic and treatment strategies. Recent research has focused on the role of serum neurofilament light (sNfL), a marker for neuro-axonal injury, in BD. Highlights: Individuals with BD for more than three years exhibit higher sNfL levels compared …
Attention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset neurodevelopmental disorder characterized by developmentally inappropriate levels of inattention, hyperactivity, and impulsivity. While highly heritable, the heterogeneity of clinical presentation suggests complex interactions between genetic and environmental risk factors. A new study suggests that it may be possible to diagnose ADHD or detect ADHD susceptibility risk in children …