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Zembrin® (Sceletium tortuosum) for Anxiety & Depression: Testing Alkaloid-Specific Effects (2023 Study)

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Sceletium tortuosum (ST) Extract, known as Zembrin®, is a traditional South African remedy was recently evaluated for its nuanced effects on anxiety and depression through a unique study using zebrafish larvae. Highlights: Zebrafish Larvae as Model Organisms: A study used zebrafish larvae to observe Zembrin®’s anxiolytic & antidepressant-like effects, offering a detailed and dynamic understanding …

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Considering Lactate in Psychiatric Disorders & Drug Development (2023 Review)

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Lactate, traditionally viewed as a simple metabolic byproduct, is emerging as a significant player in the realm of psychiatric disorders. Recent research reveals its intricate role as both an energy source and a signaling molecule, potentially influencing a wide array of mental health conditions. Highlights: Shift in Lactate Perception: The review highlights a paradigm shift …

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Mycobacterium vaccae Vaccine: A Novel Soil Bacteria-Based Treatment for Anxiety & Stress Disorders

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Stress can induce anxiety and depression, which appears to be mediated in part by stress-induced neuroinflammatory processes. The immunoregulatory bacterium Mycobacterium vaccae (M. vaccae) has anti-inflammatory and stress-resilient effects, but its impact on the brain is unclear. A study discovered that M. vaccae immunization: induces anti-inflammatory and immunoregulatory processes in the hippocampus, blocks stress-induced neuroinflammation …

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Oral Contraceptive Pill Pause & Withdrawal Linked to Depression & Anxiety in Young Women (Study)

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A recent study has shed new light on the mental health implications of hormonal contraceptives, particularly focusing on the period known as the ‘pill pause.’ Research indicates that temporarily stopping synthetic hormone intake during this break can lead to increased negative emotions and anxiety among long-term contraceptive pill users. This finding challenges the conventional approach …

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Depressed vs. Anxious Brains: Differences in Brain Waves & Connectivity Revealed

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Advanced analysis of multidimensional EEG data reveals significant differences in brain activity patterns between Generalized Anxiety Disorder (GAD) and Depressive Disorder (DD). The distinguishing factors seem to be differences in beta brain waves and functional connectivity between various brain regions. Key Facts: Patients with DD exhibited higher power spectrum density (PSD) values and fuzzy entropy …

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Doxycycline Causes Depression, Anxiety, Suicidal Ideation?

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Doxycycline is a broad-spectrum tetracycline antibiotic that kills bacteria and protozoa by inhibiting protein synthesis (aminoacyl-tRNA to the mRNA-ribosome complex).  The drug was patented in 1957, introduced as a pharmaceutical in 1967, and has received medical approval as a treatment for conditions such as: acne, bacterial pneumonia, chlamydia, cholera, Lyme disease, Rocky Mountain spotted fever, …

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