A 2026 Nature Neuroscience study found that lecanemab cleared amyloid in a humanized-microglia Alzheimer’s disease model only when microglia and the antibody’s intact Fc fragment were both present: X-34 plaque area differed across IgG1, lecanemab, and Fc-silenced LALA-PG groups (P = 0.0003), 82E1 plaque area differed across groups (P < 0.0001), and microglia-deficient mice showed …
A 2026 total-body tau-PET study of 28 people with Alzheimer’s disease and 23 biomarker-negative controls found stronger brain-organ network connectivity in Alzheimer’s disease than in biomarker-negative controls: 35 altered connections, including 21 brain-body edges, plus AD-only links between brain-organ coupling, cortical tau burden, MRI-derived glymphatic markers, and cognition.1 The result is best read as a …
Until recently, Alzheimer’s pathology could only be confirmed in living patients via PET imaging or lumbar puncture. Plasma p-tau217 changed that calculus — but how to interpret a positive result depends substantially on APOE genotype.1 Research Highlights Plasma p-tau217 is a blood biomarker that rises years before Alzheimer’s symptoms. The 2024 Alzheimer’s Association revised criteria …
Loneliness raises measured risk of Alzheimer’s, suicidal ideation, and completed suicide. The associations are documented; the precise magnitudes are not.
Repetitive transcranial magnetic stimulation (rTMS) is making waves in the field of Alzheimer’s disease (AD) research, offering a glimmer of hope for enhancing cognitive functions in patients. By targeting specific brain regions, rTMS has shown promising results in modulating neural activity and improving cognitive scores. This innovative therapy, coupled with real-time monitoring through electroencephalography (EEG), …
In the quest for more effective treatments for Alzheimer’s Disease (AD), berberine, a bioactive compound derived from traditional Chinese medicine, has emerged as a promising candidate. Recent preclinical studies have showcased its potential to combat the debilitating effects of AD, with evidence pointing towards its ability to improve cognitive functions, reduce hallmark AD pathologies such …
In the modern dietary landscape, ultra-processed foods (UPFs) have become a staple in many diets, celebrated for their convenience and palatability. However, emerging research reveals a concerning association between UPF consumption and increased risk of Alzheimer’s disease (AD), a leading cause of dementia. Highlights: Strong Link: Recent systematic reviews indicate a strong link between high …