A 2022 Nature Communications study used non-contrast 3D T2-FLAIR magnetic resonance imaging (MRI) to map human brain lymphatic signals in living people, including apparent channels from cranial nerves and skull-base structures toward cervical lymph nodes. Research Highlights Non-contrast MRI visualized lymphatic-like brain drainage: Albayram et al. identified dorsal dural signals near venous sinuses and ventral …
A 2026 Molecular Psychiatry study found that oral FP802 disrupted the NMDAR/TRPM4 death complex and preserved memory-task performance in 5xFAD Alzheimer’s mice treated for 3 months.1 The finding is mechanistically sharper than a generic anti-amyloid claim: FP802 targeted a glutamate-toxicity complex downstream of amyloid stress. Research Highlights Complex formation was blocked: 5xFAD mice had increased …
In APP/PS1 Alzheimer's model mice, deleting PTP1B or treating with the allosteric inhibitor DPM-1003 improved memory behavior, lowered amyloid burden, and pushed microglia toward SYK-driven clearance — a plausible mechanism, not a human treatment result yet.1 Research Highlights PTP1B loss improved behavior in APP/PS1 mice. Genetic deletion and DPM-1003 treatment improved novel object recognition and …
A 2026 mechanistic review linked microplastics to 6 proposed Alzheimer’s disease pathways and 6 proposed Parkinson’s disease pathways.1 The calibrated interpretation is that microplastics are biologically plausible brain stressors, but the human evidence does not yet prove that they cause Parkinson’s disease or Alzheimer’s disease. Research Highlights Exposure is widespread: the review cited an estimate …
A 2026 Nature Neuroscience study from the Igarashi lab proposes a circuit-level answer for why the lateral entorhinal cortex (LEC) is the first cortical region to falter in Alzheimer’s: dopamine inputs from the VTA and substantia nigra to the LEC go functionally silent at the earliest disease stage in an APP knock-in mouse — before …
Dementia rates in the US, UK, Netherlands, Sweden, France, and several other high-income countries have been falling for decades, despite population aging. The standard explanation — improved cardiovascular care, more education, and less smoking in later-born cohorts — is real but incomplete. Research Highlights Dementia incidence has been falling about 13% per decade in Western …
A 2026 medRxiv meta-analysis of 27 trials found that transcranial direct current stimulation added to cognitive training improved global cognition immediately after treatment by SMD 0.36 compared with cognitive training alone.1 The signal was small, short-term, and rated very low certainty, so it is not evidence that tDCS is a durable cognitive-rehabilitation shortcut. Research Highlights …