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XGBoost Suicide Risk Model Reached 96% PPV at Top 0.1% Threshold

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A 2026 Scientific Reports study of Maryland suicide-death records found that an XGBoost machine-learning model could reach 96.1% positive predictive value in hospital-discharge data at the top 0.1% risk threshold, but it still detected only 46.7% of suicide deaths in that cohort. Research Highlights Precision improved at the narrowest threshold: XGBoost reached PPV 0.961 in …

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AI Chatbot for Pregnancy Anxiety: 300-Woman Study Shows Large Score Drop

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A 300-woman high-risk pregnancy study reported a striking before-after change after 4 weeks of daily Replika chatbot use: Pregnancy Anxiety and Stress Rating Scale scores fell from 54.05 to 10.15, p < 0.001.1 The result is a real signal for digital maternal support, but the no-control design makes it weak evidence that the chatbot itself …

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Maternal COVID-19 and Autism Screening: 10.1% Positive MCHAT-R/F

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A 745-child cohort found positive MCHAT-R/F autism screens in 22 of 218 children exposed to maternal SARS-CoV-2 infection during pregnancy (10.1%) vs. 30 of 527 pre-pandemic controls (5.7%; p = 0.03).1 The same 2026 analysis added a small serum-proteomics layer: exposed newborns who later screened positive showed altered immune and metabolic markers, but the paper …

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High Cytokines Predicted Weaker Placebo Response in Cancer Symptom Trial

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A 2026 exploratory analysis of the ABCD cancer dyspnea trial found that higher baseline cytokines predicted less placebo symptom improvement than lower baseline cytokines across 33 of 40 cytokine-symptom combinations at day 7 and 29 of 40 at day 14.1 The signal is not ready for clinical prediction, but it sharpens a trial-design problem: patients …

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Early Psychosis Vocational Recovery: 53.3% NEET in SEEearly Trial

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A 2026 SEEearly baseline report found that 53.3% of 184 young people with early schizophrenia-spectrum psychosis were not in employment, education, or training at study entry, even though 97.8% had at least a lower- or upper-secondary school-leaving qualification.1 Psychosis had already interrupted the bridge from school into training, college, or competitive work. Research Highlights NEET …

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