hit counter

Topamax (Topiramate) For Migraines: An Effective Prophylactic?

Topamax (Topiramate) is an anticonvulsant agent discovered in 1979 by Bruce Maryanoff and Joseph Gardocki while working for McNeil Pharmaceutical (a subsidiary of Johnson & Johnson).  When compared to other anticonvulsant agents, Topamax is regarded as unique in that it is pharmacologically classified as a sulfamate-substituted monosaccharide derivative, indicating that its chemical structure is similar …

Read more

Nortriptyline For Migraines: An Alternative Prophylactic

Nortriptyline is a tricyclic antidepressant (TCA) that was initially FDA approved in 1964 (under the brand name “Pamelor”) for the treatment of major depression.  It is regarded as chemical successor to Amitriptyline based on the fact that Nortriptyline is Amitriptyline’s predominant psychoactive metabolite.  Since Nortriptyline has been on the market since the mid-1960s, researchers are …

Read more

Amitriptyline For Migraines: An Effective Prophylactic Agent

Amitriptyline (brand name “Elavil”) is a medication that was initially approved by the FDA in 1961 for the treatment of major depressive disorder.  Due to its three-ring chemical structure, it is formally classified as a tricyclic antidepressant (TCA).  Though not formally approved in the United States to treat conditions other than major depression, Amitriptyline is …

Read more