MentalHealthDaily

Addiction Medications in 371 Trials: No Approved Medication for Stimulant Use Disorder

by GLOOM

MHD card showing a medication blister pack: the strongest addiction-medication evidence is for smoking and opioids; no medication is approved for stimulant use disorder.

A 2026 umbrella review of 16 systematic reviews covering 371 trials found strong medication evidence for tobacco and opioid use disorders, modest benefits for alcohol use disorder, and no approved drugs for stimulant or cannabis use disorders.1 Varenicline more than doubled smoking quit rates vs. placebo, methadone kept people in opioid treatment longer than buprenorphine, …

How Long Does Chantix Stay In Your System?

by GLOOM

Chantix (Varenicline) is a drug marketed by Pfizer for the treatment of nicotine addiction. It functions as a selective, competitive partial agonist at α4β2 (alpha-4-beta-2) nAChRs. Competitive partial agonism at the α4β2 receptors decreases the binding of nicotine to these receptors, thereby modulating the release of dopamine in the mesolimbic pathway as triggered by nicotine …