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Nortriptyline-Induced “Room Tilt Illusion”: A Rare Adverse Event of Antidepressants (2024 Case Report)

Room Tilt Illusion (RTI) presents a perplexing challenge to both patients and physicians, transforming the familiar into the surreal as surroundings appear rotated or flipped. This rare condition, often linked to neurological or vestibular disorders, has recently been observed as an adverse effect of the antidepressant nortriptyline, used in treatment-resistant depression. A case report highlights …

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Nortriptyline For Migraines: An Alternative Prophylactic

Nortriptyline is a tricyclic antidepressant (TCA) that was initially FDA approved in 1964 (under the brand name “Pamelor”) for the treatment of major depression.  It is regarded as chemical successor to Amitriptyline based on the fact that Nortriptyline is Amitriptyline’s predominant psychoactive metabolite.  Since Nortriptyline has been on the market since the mid-1960s, researchers are …

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