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Methylphenidate Reduced Dishonesty and Cheating in 151 Adults; Atomoxetine Had No Effect

Editorial card showing methylphenidate molecular structure beside a die-rolling task, illustrating a counterintuitive randomized-trial result.

A 2026 double-blind randomized controlled trial by Kappes et al. in Psychopharmacology found something the smart-drug users likely wouldn’t have predicted: a single 30 mg dose of methylphenidate reduced dishonest misreporting on a die-rolling task from ~22% of trials in the placebo arm to ~6% (in the methylphenidate arm).1 Atomoxetine, a noradrenergic comparator, had no …

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Safest Psychiatric Drugs: Low Risk, Effective Medications

Reports suggest that nearly 20% of all people in the United States are taking a psychiatric drug.  This means that 1 out of every 5 people you see is on some sort of mind-altering medication.  Although many of these drugs are marketed as being “safe and effective” for conditions like ADHD, anxiety, bipolar disorder, depression, …

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Strattera vs. Adderall: Comparison

An overwhelming majority of medications used to treat ADHD (attention-deficit/hyperactivity disorder) are classified as psychostimulants.  Although psychostimulant drugs tend to have an immediate effect in reducing symptoms of attentional deficits and hyperactive behavior, they have a high potential for abuse.  Furthermore, there is something to be said for the potential that long-term psychostimulant use may …

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Strattera & Weight Loss: What You Should Know

Strattera (Atomoxetine) is a relatively well-known NRI (norepinephrine reuptake inhibitor) that is commonly used for the treatment of ADHD. Its mechanism of action involves inhibiting the reuptake of the neurotransmitter norepinephrine, thereby increasing extracellular levels. This tends to result in a stimulating effect, which boosts overall cortical activity and helps improve cognitive function among those …

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Strattera (Atomoxetine) For Depression: Norepinephrine Reuptake Inhibitors

Strattera is an NRI or “norepinephrine reuptake inhibitor” meaning it prevents the reuptake of the neurotransmitter norepinephrine. This drug has been found clinically effective for treating cases of ADHD. Many doctors prefer to prescribe this drug over a potent stimulant like Adderall simply because it doesn’t have any major addictive properties or potential for abuse. …

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