responsive neurostimulation Archives

Closed-Loop Subgaleal ISP Reduced Epilepsy Seizure Incidence 80%

by GLOOM

Editorial card showing subgaleal electrode strips, closed-loop seizure detection, and focused neurostimulation for therapy-resistant epilepsy.

A 2026 first-in-human medRxiv preprint reported that closed-loop subgaleal intersectional short-pulse stimulation shortened stimulated seizures by 52% on average and reduced seizure incidence by 80.9% after 48 hours in 5 high-frequency therapy-resistant epilepsy patients. The signal is promising because it combines responsive seizure detection with electrode strips placed under the scalp rather than electrodes implanted …

VNS After Failed Epilepsy Surgery Reduced Seizures 76% at 36 Months

by GLOOM

Photoreal illustration showing an implanted vagus nerve stimulator and brain pathways, representing neuromodulation for drug-resistant epilepsy.

A 2026 CORE-VNS registry analysis found that implanted vagus nerve stimulation still produced large 36-month seizure reductions after failed intracranial epilepsy surgery: median all-seizure reduction was 76.3% with prior surgery vs. 76.6% without prior surgery.1 Research Highlights Prior surgery did not blunt the main VNS signal: CORE-VNS reported 76.3% median all-seizure reduction at 36 months …

New Epilepsy Treatments (2023): Neurostimulation, CBD, Gene Therapy for Seizures

by GLOOM

Epilepsy affects over 50 million people worldwide, making it one of the most common neurological disorders globally. For many living with epilepsy, achieving reliable seizure control remains a significant challenge, underscoring the need for continued innovation in treatment approaches. Exciting new developments in the field are providing clinicians with an expanding array of therapeutic options …