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Psilocybin for Major Depression in Adults (2023 Evidence Review)

The emerging research into psilocybin, a classical psychedelic, reveals its significant potential in treating Major Depressive Disorder (MDD). Historically used in spiritual and shamanic practices, psilocybin’s recent clinical studies have opened new avenues in mental health treatment, challenging traditional antidepressants like SSRIs. Highlights: Psilocybin’s Historical & Clinical Relevance: A natural compound used for millennia, recent …

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How Long Do “Shrooms” Stay In Your System? (Psilocybin)

“Shrooms” commonly refers to over 200 species of mushrooms containing the active psychedelic compound known as “psilocybin.”  Psilocybin itself is a prodrug, meaning it is inactive until ingested and broken down (metabolized) within the body.  Upon metabolism of psilocybin, it is converted to the active metabolite “psilocin” which functions primarily as a 5-HT2A receptor partial …

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