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Residual Sleepiness in Treated Sleep Apnea Linked to Memory Deficits

Stylized sleep-apnea treatment scene with CPAP, daytime sleepiness testing, and memory-task circuitry, representing cognitive deficits linked to residual sleepiness despite PAP adherence.

Some sleep apnea patients stay sleepy even when their CPAP is used 6+ hours a night and apnea events have been driven back to normal range. A 2026 cross-sectional study of 65 PAP-adherent adults found those residually sleepy patients performed measurably worse on global cognition, memory, executive function, attention, and processing speed than their well-rested …

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Reset Modafinil Tolerance with Drug Holidays & Pitolisant-Bridging? (2023 Study)

Narcolepsy, a chronic neurological disorder, significantly impacts the daily lives of those affected due to excessive daytime sleepiness (EDS). Modafinil has been a cornerstone in managing EDS, but its effectiveness can wane over time due to tolerance. An innovative approach, using the drug pitolisant during modafinil ‘drug holidays’, offers new hope for resetting tolerance and …

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