MentalHealthDaily

Nortriptyline-Induced “Room Tilt Illusion”: A Rare Adverse Event of Antidepressants (2024 Case Report)

Room Tilt Illusion (RTI) presents a perplexing challenge to both patients and physicians, transforming the familiar into the surreal as surroundings appear rotated or flipped. This rare condition, often linked to neurological or vestibular disorders, has recently been observed as an adverse effect of the antidepressant nortriptyline, used in treatment-resistant depression. A case report highlights …

How Long Does Nortriptyline Stay In Your System?

by GLOOM

Nortriptyline (brand name “Pamelor”) is considered the chief pharmacologically active metabolite of the chemical amitriptyline, a tricyclic antidepressant derived from dibenzocycloheptene. Formation of nortriptyline occurs upon hepatic oxidative N-demethylation of amitriptyline via CYP2D6 and CYP2C19 isoenzymes. In the early 1960s, researchers realized a significant portion of amitriptyline’s antidepressant effects resulted from the formation of its …

Nortriptyline Withdrawal Symptoms + Duration

by GLOOM

Nortriptyline (Pamelor) is a tricyclic antidepressant that is commonly used as a second-line treatment for major depression. It is also sometimes prescribed for conditions such as chronic fatigue syndrome, bedwetting in children, migraine headaches, and neuropathic pain. The drug may also be effective for some individuals in managing symptoms of attention-deficit hyperactivity disorder (ADHD). This …