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Adult Hippocampal Neurogenesis Added 670,000 Rat Dentate Neurons

MHD featured image for adult hippocampal neurogenesis and dentate gyrus neuron turnover.

A 2026 rat study estimated that adult hippocampal neurogenesis added 670,000 dentate gyrus granule neurons from 2 to 18 months of age, but the total dentate gyrus population grew by only 385,000 cells because older developmentally born neurons were also being lost.1 The result makes adult neurogenesis look numerically larger than the usual “tiny trickle” …

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Berberine for Depression: Mechanisms & Antidepressant Effects (2024 Review)

Depression, a pervasive global health issue, significantly impairs quality of life and burdens the healthcare system. Despite the availability of numerous antidepressants, their effectiveness is often limited, pushing researchers to explore alternative treatments. Berberine, a natural compound with a diverse pharmacological profile, has shown promising antidepressant effects, offering a potential complementary or alternative approach to …

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CBD Oil For Anxiety: Is Cannabidiol An Effective Treatment?

Cannabidiol (CBD) is just one of over 85 scientifically-identified cannabinoids (or chemical compounds) derived from the flowering plant cannabis.  Each of the cannabinoids within cannabis elicit unique neurophysiological effects.  Most people are well-aware of THC (tetrahydrocannabinol), the predominant cannabinoid within cannabis that is ingested by upwards of 230 million people per year as a psychoactive …

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NSI-189 For Depression: New Drug Grows Hippocampus

Individuals diagnosed with major depression often are found to have reduced volume within their hippocampus. The hippocampus is a small region of the brain that is responsible for regulating various memory and spatial navigation functions. It is also believed to play a pivotal role in the regulation of mood. Modern day antidepressants such as SSRIs …

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