In a 2026 case report from China, a 34-year-old woman with mild intellectual disability was sent for evaluation of possible narcolepsy. Sleep testing and EEG instead showed epilepsy and moderate obstructive sleep apnea.1 Research Highlights Narcolepsy was ruled unlikely: she took 9.3 minutes on average to fall asleep during daytime nap tests, with no early …
Narcolepsy, a chronic neurological disorder, significantly impacts the daily lives of those affected due to excessive daytime sleepiness (EDS). Modafinil has been a cornerstone in managing EDS, but its effectiveness can wane over time due to tolerance. An innovative approach, using the drug pitolisant during modafinil ‘drug holidays’, offers new hope for resetting tolerance and …
Narcolepsy is a neurological disorder associated with the brain’s inability to regulate sleep-wake cycles (and the circadian rhythm). As a result, individuals diagnosed with narcolepsy often experience excessive daytime sleepiness and may fall asleep unexpectedly. Some have suggested that the excessive daytime sleepiness stemming from narcolepsy is akin to how a normal person feels if …
Provigil (modafinil) is a drug that was approved in 1998 for the treatment of excessive daytime sleepiness associated with narcolepsy. It has since been granted FDA approval for the treatment of obstructive sleep apnea as well as shift work sleep disorder. Adderall (mixed amphetamine salts) is a psychostimulant drug that was initially approved in 1996 …
Nearly everyone has had a day where they feel so tired during the day, that they have a difficult time staying awake. For a majority of individuals, the tiredness is caused by insufficient sleep and/or a possible hangover from partying too hard the previous night. However, some people battle a condition known as “excessive daytime …