A 2026 study by Bai et al. in Dialogues in Clinical Neuroscience uses Mendelian randomization (MR) — inherited genetic variants as a natural experiment to test causality — and concludes that migraines causally lower cognitive performance in a Han Chinese sample.1 The headline conclusion is plausible; the effect-size numbers in the popular MR shorthand (odds …
A 2026 review argued that G protein-coupled receptor 30 may connect estrogen signaling, trigeminal pain pathways, and migraine biology, but migraine-specific human trials of GPR30-targeted drugs are still missing. Research Highlights The migraine rationale is hormone-linked: women have roughly 2 to 3 times the migraine prevalence of men, and 50% to 60% of women with …
Migraine, a primary headache disorder, significantly impacts the quality of life of millions worldwide. In recent years, the focus has shifted toward developing targeted therapies, particularly monoclonal antibodies (mAbs) against the calcitonin-gene-related peptide (CGRP), to prevent chronic migraine attacks. A relatively recent comprehensive network meta-analysis (NMA) evaluated the efficacy and safety of various anti-CGRP mAbs, …
A Daith piercing is a specific type of ear piercing in which the ear’s innermost cartilage fold (i.e. the crus of helix) is penetrated and pierced with a specialized curved needle. According to experts, for a piercing to qualify as a legitimate “Daith piercing” – it must be performed such that the bottom part of …
Zoloft (Sertraline), is an SSRI (selective serotonin reuptake inhibitor) prescribed for the treatment of major depressive disorder, OCD (obsessive-compulsive disorder), panic disorder, and social anxiety disorder. It was approved by the FDA in 1991 and initially marketed by the pharmaceutical company Pfizer. In 2013, Zoloft became the single most popular antidepressant medication in the United …