Mental Health DailyResearch. Evidence. Perspective.Published research on microglia.
In a 2026 study of 40 male rats under 6 weeks of daily restraint stress, 2 weeks of celecoxib improved open-field, maze and swim-test behavior and lowered hippocampal TNF-alpha, IL-1beta, IL…
Read articleIn rats with toxin-damaged cerebellums, 4 weeks of the blood-pressure drug losartan reduced oxidative damage, inflammation and tissue injury. A nanoparticle version did better on several tis…
Read articleGuanfacine, a non-stimulant ADHD medication, reduced hyperactivity in autistic children in a placebo-controlled trial. A 2026 review argues it may also steady prefrontal brain signaling and …
Read articleA 2026 Glia analysis found a shared microglial transcriptional program across 5 neurodegenerative contexts: ALS, frontotemporal dementia, Alzheimer’s disease, aging, and Parkinson’s disease.…
Read articleA 2025 Nature Communications study found that Alzheimer’s-like mice lost locus coeruleus noradrenergic axons in the olfactory bulb early: 14% loss by 2 months, 27% by 3 months, and 33% by 6 …
Read articleIn APP/PS1 Alzheimer's model mice, deleting PTP1B or treating with the allosteric inhibitor DPM-1003 improved memory behavior, lowered amyloid burden, and pushed microglia toward SYK-driven …
Read articleA human, mouse, and zebrafish study linked long-term chlorpyrifos exposure to Parkinson’s disease risk, with the strongest exposure-duration estimate reaching OR 2.74 for workplace proximity…
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