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T2943 Treats Depression via Epigenetics: HDAC5 Inibitor in Hippocampus (2024 Study)

Depression remains one of the most pervasive and challenging mental health conditions, affecting millions worldwide with a significant number not responding to traditional treatments. Emerging research underscores the role of histone modifications in depression, pointing towards epigenetic mechanisms as potential targets for novel antidepressants. Specifically, a compound known as T2943 (a histone deacetylase-5 (HDAC5) inhibitor), …

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D-Cycloserine Targets the NMDA Receptors to Enhance Synpatic Plasticity in Hippocampus (2024 Study)

In the complex and evolving field of neuroscience, the role of synaptic plasticity in psychiatric disorders has garnered significant attention. d-Cycloserine (DCS), a partial agonist of the N-methyl-D-aspartate receptor (NMDAR), emerges as a key player in potentially revolutionizing treatment approaches. Highlights: d-Cycloserine (DCS): Initially an antimicrobial agent, DCS is now known for its role as …

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NSI-189 For Depression: New Drug Grows Hippocampus

Individuals diagnosed with major depression often are found to have reduced volume within their hippocampus. The hippocampus is a small region of the brain that is responsible for regulating various memory and spatial navigation functions. It is also believed to play a pivotal role in the regulation of mood. Modern day antidepressants such as SSRIs …

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