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Autism With ADHD Linked to Weaker Brain Connectivity Than Autism Alone

MHD card with a row of five metronomes on a dark shelf against a deep teal background; three on the left swing in step with glowing teal arms while two on the right are dim and out of step, illustrating weaker brain connectivity in autism with ADHD.

Autistic young people who also have ADHD showed weaker resting brain connections than autistic peers without ADHD, according to a 2026 brain-imaging study of 69 people.1 Most autism-linked differences were shared by both autistic groups, but the extra ADHD diagnosis came with its own pattern, especially in a brain area that helps with attention and …

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qMRI Brain Aging Maps Myelin, Iron, and Water in 138 Adults

MHD featured image for qMRI brain aging maps of myelin, iron, and water.

A 2026 quantitative MRI preprint reanalyzed 138 healthy adults and found that multivariate modeling detected coordinated age-related shifts across myelin-sensitive, iron-sensitive, and water-sensitive brain maps.1 The signal was broad, but split-half validation weakened the result enough to keep it in the measurement-method lane rather than the clinical-test lane. Research Highlights 138 adults were reanalyzed: The …

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FTL1 Iron Protein Reversal Improved Cognitive Aging in Old Mice

MHD featured image for FTL1, iron biology, and cognitive aging in mice.

A 2025 Nature Aging study found that hippocampal ferritin light chain 1 (FTL1) rose with age in mouse neurons, tracked poorer cognition, and became experimentally reversible in old mice. This is an animal-mechanism result, not a human anti-aging treatment.1 Research Highlights FTL1 rose in aged hippocampus: Western blot data showed higher hippocampal FTL1 in aged …

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CA3 Memory Circuit Connectivity Falls From 6.37% to 2.17%

MHD featured image for hippocampal CA3 memory-circuit development research.

A 2026 Nature Communications mouse study tested 7,736 possible connections in the hippocampal CA3 memory circuit and found a developmental shift from dense early wiring toward sparse structured adult wiring: corrected CA3-to-CA3 connection probability fell from 6.37% at P7-8 to 2.17% at P45-50.1 The finding supports a circuit-level version of memory maturation, not a claim …

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Catatonia Brain Circuits: Limbic System Review

MHD featured image for catatonia, limbic-system brain circuits, and psychomotor shutdown.

A 2026 systematic review argues that catatonia should be read as a limbic-cortical circuit syndrome, with motor shutdown tied to brain systems for threat, salience, motivation, and emotional regulation. Research Highlights 20 studies met criteria: the 2026 review screened 1,792 records, assessed 54 full texts, and included 20 articles: 13 observational studies and 7 case …

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