A 2026 PREDIMED-Plus cohort analysis linked higher olive-oil intake with 2-year cognitive preservation in 656 older adults, with each 10 g/day increment associated with higher global cognition change compared with lower intake (beta 0.044 z-score; 95% CI 0.013 to 0.075; p = 0.006).1 The more specific signal favored virgin olive oil and gut-microbiome diversity, while …
A 2025 Journal of the American Chemical Society study identified 4 unusual Morganella morganii phospholipids that activated TLR2/TLR1 immune receptors and induced inflammatory cytokines, especially IL-6.1 The finding does not prove that one gut bacterium causes depression, but it gives the microbiome-depression field something it often lacks: a named molecule and a receptor pathway. Research …
An 11-person case series tested delayed-release apple cider vinegar capsules in young adults who had gained weight while taking psychotropic medications, and metabolic markers carried more signal than weight loss. Research Highlights Feasibility was the strongest result: 11 of 12 enrolled participants completed the study, 10 of 11 completers missed 5 or fewer doses, and …
The intricate relationship between the gut microbiome and major depressive disorder (MDD) is gaining significant attention within the scientific community. Emerging research highlights sex-specific disparities in the gut microbiome’s composition and its potential impact on MDD, pointing towards the necessity of integrating sex as a biological variable in future studies. Highlights: Sex Disparities in MDD: …
The gut-brain axis, a complex communication network linking the gastrointestinal tract and the brain, plays a pivotal role in maintaining both mental and physical health. Recent studies illuminate how chronic stress disrupts this intricate system, particularly affecting the intestinal barrier in the jejunum, and contributes to the pathogenesis of Major Depressive Disorder (MDD). This emerging …
Depression, a multifaceted disorder characterized by pervasive sadness and lack of interest, extends beyond the brain to implicate the entire body, including the gut. Recent research has illuminated the significant role that gut microbiota plays in Major Depressive Disorder (MDD), suggesting a complex interplay between our microbial inhabitants and mental health. Highlights: Gut Microbiota & …
Patients with severe mental illnesses (SMI), such as schizophrenia and chronic depression, often face the challenge of managing weight gain and metabolic complications, side effects commonly associated with antipsychotics and antidepressants. These medications are known to induce increased appetite and weight gain, leading to long-term metabolic syndromes. Recent studies have evaluated into the role of …