A 2026 mouse and cell study found that ATP11B loss pushed aged brains toward hippocampal iron accumulation, mitochondrial dysfunction, neuronal ferroptosis, and worse memory behavior than wild-type comparison mice; ATP11B overexpression then improved multiple learning and memory tests in 18-month-old mice. Research Highlights Memory signal: ATP11B-deficient mice performed worse than wild-type mice on Morris water …
A 2026 Cell & Bioscience study found that poly-GR, one of the toxic dipeptide-repeat proteins produced in C9orf72-linked amyotrophic lateral sclerosis (ALS), pushed motor neuron-like cells toward ferroptosis: 4-HNE lipid peroxidation rose at p < 0.0001, labile Fe²+ rose at p < 0.001, and erastin caused more cell death in poly-GR-expressing cells than in control …
Depression, a debilitating mental disorder, stands as a significant challenge to global health, potentially becoming the leading cause of disability worldwide. Recent research has unearthed a promising connection between ferroptosis, a newly discovered form of cell death, and the onset of depression, offering fresh avenues for developing innovative antidepressant therapies. Traditional Chinese Medicine (TCM) and …