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GPR30 and Migraine: Estrogen Link Still Lacks Human Trials

MHD featured image for GPR30, estrogen signaling, trigeminal ganglion biology, and migraine.

A 2026 review argued that G protein-coupled receptor 30 may connect estrogen signaling, trigeminal pain pathways, and migraine biology, but migraine-specific human trials of GPR30-targeted drugs are still missing. Research Highlights The migraine rationale is hormone-linked: women have roughly 2 to 3 times the migraine prevalence of men, and 50% to 60% of women with …

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Oral Contraceptive Pill Pause & Withdrawal Linked to Depression & Anxiety in Young Women (Study)

A recent study has shed new light on the mental health implications of hormonal contraceptives, particularly focusing on the period known as the ‘pill pause.’ Research indicates that temporarily stopping synthetic hormone intake during this break can lead to increased negative emotions and anxiety among long-term contraceptive pill users. This finding challenges the conventional approach …

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20 Foods High In Estrogen (Phytoestrogens)

Estrogen is considered a female sex hormone produced by the ovaries in women. Without adequate levels of estrogen, women may notice that they feel moody, unhealthy, or are unable to maintain healthy female sex characteristics.  Estrogen is an essential hormone for maintenance of feminine sex traits, but also plays an important role in physiological functions such …

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