Buspar (Buspirone) is a drug of the azapirone chemical classification that was engineered and patented in the 1970s by Mead Johnson. It was later acquired by the pharmaceutical company Bristol-Myers Squibb and approved by the FDA in 1986 for the treatment of generalized anxiety disorder (GAD). What’s unique about buspirone compared to other anxiolytics such …
Phentermine is a natural monoamine alkaloid derivative that was initially approved by the United States FDA in 1959 as an anorectic (appetite suppressant) for the treatment of obesity. It was popularized throughout the early 1970s under the brand name medication “Fastin,” marketed by King Pharmaceuticals. In the late 1990s phentermine was discontinued from pharmaceutical circulation, …
Qsymia is a weight loss drug engineered by the California-based pharmaceutical company Vivus Inc. It was initially approved by the FDA in 2012 for weight reduction among adults with BMIs (body mass indexes) exceeding 30 kg/m² as an adjunct to interventions such as caloric restriction, dietary modification, and regular exercise. Qsymia is also approved for …
Naltrexone is a chemical initially synthesized in 1963 and patented thereafter by the pharmaceutical company Endo Laboratories in 1967. It is considered a substituted derivative of oxymorphone in that the tertiary amine methyl-constituent is replaced with an allyl group (specifically an N-cyclopropylmethyl group) – or a longer chain of carbon atoms. It was initially approved …
Naltrexone is a pure opioid receptor antagonist utilized principally for the treatment of alcohol and opioid dependence. As an opioid receptor antagonist, naltrexone competitively binds to mu-opioid receptor (MOR) and kappa-opioid receptor (KOR) sites with higher affinity than opioid agonists, thereby attenuating receptor activation. Should an individual administer an opioid agonist (e.g. morphine) while taking …
Sumatriptan (brand names “Imitrex”) is a synthetic medication that was initially approved in 1991 for the treatment of migraine and cluster headaches. Chemically, it is classified as a “triptan” or tryptamine-based agent and is identified as a structural analogue of various alkaloids such as bufotenine and DMT (dimethyltryptamine). When administered following the onset of a …
Fioricet is a medication approved by the FDA for the treatment of three specific types of headaches including: tension, muscle contraction, and post-dural puncture. It contains a unique blend of a barbiturate (butalbital 50 mg), a pain reliever (acetaminophen 300 mg), and a stimulant (caffeine 40 mg); hence the reason it is sometimes abbreviated as Butal-Acet-Caff. …