MentalHealthDaily

TMEV Viral Parkinson’s Mouse Model Caused 20-Week Dopamine-Lesion Behaviors

by GLOOM

MHD featured image for a viral Parkinson's mouse model using Theiler's murine encephalomyelitis virus.

A 2026 mouse study found that Theiler’s murine encephalomyelitis virus (TMEV) injected into the substantia nigra produced persistent Parkinson’s-like motor signals through 20 weeks, including apomorphine-induced rotations at every measured post-injection timepoint.1 The finding makes TMEV a useful viral-neuroinflammation model of dopamine-neuron injury, but it does not show that Theiler’s virus causes human Parkinson’s disease. …

BDNF Gene Transfection & Pramiprexole Combo Effectively Treat Parkinson’s Disease in Rat Models (2024 Study)

by GLOOM

Parkinson’s disease (PD), a degenerative disorder that predominantly affects the motor system, has long been a challenging condition to manage due to its complex pathology and the limited efficacy of available treatments. However, recent research presents a beacon of hope through a novel combined therapy targeting the core of Parkinson’s disease’s neuronal degradation. This innovative …

Dopamine & Social Status vs. Stress Responses in Mice (2023 Study)

by GLOOM

Social hierarchies are not just a human phenomenon; they’re prevalent in the animal kingdom too, particularly among social creatures like mice. A groundbreaking study on isogenic C57BL/6 mice has shed light on the intricate mechanisms that govern social hierarchy, particularly focusing on the role of dopamine and stress response. This discovery not only enhances our …