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Esketamine Can Trigger Trauma Re-Experiencing in PTSD

Photoreal illustration of a patient receiving nasal spray with overlay of trauma memory imagery, conveying esketamine + PTSD interaction.

A 2026 retrospective case series of 22 adults with treatment-resistant depression and comorbid PTSD found that trauma re-experiencing during intranasal esketamine disappeared over later sessions in 72.7% of patients, while 27.3% stopped esketamine because the flashbacks persisted.1 Research Highlights Flashbacks usually faded, but not always: In 16 of 22 patients (72.7%), esketamine-related trauma re-experiencing disappeared …

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Are Mystical Experiences Required for the Antidepressant Effects of Ketamine & Psychedelics?

The intersection of mental health treatment and pharmacology is witnessing a remarkable shift with the growing interest in ketamine and classic psychedelics like psilocybin for their rapid and sustained antidepressant effects. Unlike traditional antidepressants, these substances offer hope for those with treatment-resistant depression by potentially transforming treatment paradigms. However, it remains somewhat unclear as to …

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Dangers of Meditation: List Of Possibilities

Most people associate meditation with laser-like focus, expanded internal awareness, emotional stability, and cognitive enhancement.  Plus there is mounting evidence to suggest that many of these claims are valid, just read all of the scientific benefits of meditation.  The new wave of meditation science, coupled with development of meditation apps (e.g. Headspace), and celebrities attributing their success …

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