MentalHealthDaily

Gene Editing with CRISPR/Cas9 to Treat Corticosteroid-Induced Neuropsychiatric Disorders (2023 Review)

by GLOOM

The widespread use of corticosteroids (CCSs) across the globe for treating inflammatory conditions has led to an increased incidence of corticosteroid-induced neuropsychiatric disorders (NPDs), raising significant public health concerns. These disorders range from depression and anxiety to severe cognitive changes, challenging the medical community to find effective treatments. The exploration of genetic and epigenetic factors …

Intranasal CRISPR Gene Editing for Anxiety via HTR2A Gene (5-HT2A Receptors) in Mice (2023 Study)

by GLOOM

The innovative use of CRISPR/Cas9 gene-editing technology has taken a leap forward in mental health treatment. A new study has demonstrated the successful noninvasive intranasal delivery of this technology to modify neural circuits in the central nervous system, targeting the HTR2A gene associated with anxiety and depression. This breakthrough offers a glimpse into the future …

Brain Gene Editing with CRISPR-Cas9 RNPs as Non-Viral Vector Alternative in Mice (2023 Study)

by GLOOM

CRISPR-Cas9 technology, a powerful tool for gene editing, has made significant strides in therapeutic applications, especially within the central nervous system (CNS). A recent study highlights the potential of non-viral delivery of CRISPR-Cas9 ribonucleoproteins (RNPs) into the mouse striatum, offering a promising alternative to viral vector-based delivery. Highlights: Non-Viral Delivery of CRISPR-Cas9: The study focuses …

Autism Spectrum Disorder (ASD): Future Treatments with DNA, mRNA, Protein (CRISPR, ASOs, Drugs)

by GLOOM

Autism Spectrum Disorder (ASD) represents a complex neurodevelopmental challenge with a strong genetic component. Recent advances in molecular biology have opened new avenues for potential therapeutic interventions, targeting the condition at the DNA, mRNA, and protein levels. Highlights: ASD is a genetically diverse condition, with many cases linked to loss-of-function mutations in specific genes. Innovative …

Gene Editing (CRISPR) for Alzheimers Disease Treatment

by GLOOM

Alzheimer’s disease (AD) is an incurable neurodegenerative disease and the most common form of dementia. Research is ongoing to better understand AD pathogenesis and explore potential treatments. Genome editing tools like CRISPR/Cas9 offer new approaches to study and potentially treat AD. Key Facts: AD pathogenesis likely involves multiple genetic and environmental factors Gene mutations linked …