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Gene Editing with CRISPR/Cas9 to Treat Corticosteroid-Induced Neuropsychiatric Disorders (2023 Review)

The widespread use of corticosteroids (CCSs) across the globe for treating inflammatory conditions has led to an increased incidence of corticosteroid-induced neuropsychiatric disorders (NPDs), raising significant public health concerns. These disorders range from depression and anxiety to severe cognitive changes, challenging the medical community to find effective treatments. The exploration of genetic and epigenetic factors …

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Why Prednisone Causes Weight Gain (And What To Do About It)

Prednisone is a synthetic pregnane corticosteroid that was first identified in 1950 by the American microbiologist Arthur Nobile, and thereafter, synthesized in 1955 by the Schering Corporation.  As a synthetic derivative of cortisone, prednisone acts by mimicking the physiologic effects of cortisol, the chief endogenous hormone secreted by the adrenal cortex when the body is …

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