A 2026 iScience study found that 45 days of clomipramine improved spatial, working, and reference memory in female APP/PS1 Alzheimer’s-model mice, apparently by blocking the E3 ubiquitin ligase Itch rather than by clearing amyloid plaques.1 Research Highlights 45-day clomipramine signal: 6-month female APP/PS1 mice received 25 mg/kg clomipramine every other day for 45 days, then …
Parenteral clomipramine has a strong clinical myth around it: bypass the gut, raise parent-drug exposure quickly, and maybe accelerate rescue in severe depression or OCD. A 2026 systematic review found the route advantage was not clearly proven: in depression, 5 RCTs without high risk of bias did not show clear IV or IM superiority over …
Trichotillomania is psychiatrically classified as subtype of obsessive compulsive disorder characterized chiefly by the urge to pull out one’s own hair. The condition, also known as “hair pulling disorder,” affects upwards of 2.5 million individuals in the United States at some point during their lives. Onset of trichotillomania occurs most frequently between 9 and 13 …