Chronic stress is a candidate mechanism for both depression and addiction risk. A 2026 mouse study found that 28 days of unpredictable chronic mild stress increased striatal dopamine D1 receptor binding by 22–48% across nearly every region examined, plus more selective D2 receptor increases — pointing to a stress-driven shift in reward signaling that may …
The gut-brain axis, a complex communication network linking the gastrointestinal tract and the brain, plays a pivotal role in maintaining both mental and physical health. Recent studies illuminate how chronic stress disrupts this intricate system, particularly affecting the intestinal barrier in the jejunum, and contributes to the pathogenesis of Major Depressive Disorder (MDD). This emerging …
Alzheimer’s disease, a debilitating neurodegenerative condition, is influenced significantly by a blend of genetic, environmental, and lifestyle factors. New research focuses on environmental risk factors and microglia (the brain’s immune cells) for Alzheimer’s development. Highlights: Alzheimer’s Disease and Microglia: Alzheimer’s is characterized by cognitive decline, and microglia play a crucial role in its pathogenesis, acting …