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Schizophrenia MRI Subtypes Split 3,958 Patients Into 2 Patterns

MHD featured image for schizophrenia MRI cortical-gradient subtypes.

A 2026 ENIGMA structural MRI preprint involving 3,958 people diagnosed with schizophrenia and 5,489 controls found 2 cortical-alteration subtypes rather than 1 uniform brain pattern.1 The result maps heterogeneity: anterior-cingulate and temporoparietal network patterns may separate patients, but the result is not a diagnostic MRI test. Research Highlights Large MRI base: The analysis included 3,958 …

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Escitalopram (Lexapro) Normalizes Brain Connectivity in Major Depression (2024 Study)

Major Depressive Disorder (MDD) significantly alters the brain’s network connectivity, with disturbances in the default mode network (DMN), salience network (SN), and dorsal attention network (DAN). A new study reveals how escitalopram, a common antidepressant, can partially reverse these abnormalities, offering insights into the biological underpinnings of its therapeutic effects. This research deepens our understanding …

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Mindfulness Training Improves Brain Network Connectivity Efficiency in Older Adults with Sleep Difficulties (Study)

A study suggests that mindfulness training can not only improve mindfulness, but also make functional brain reconfiguration more efficient in older adults with sleep issues. Mindfulness training enhanced measures of “mindfulness” (i.e. the quality or state of being conscious or aware) as well as functional brain connectivity patterns – relative to a control intervention. Key …

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