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How Long Does Valium Stay In Your System?

Valium (Diazepam) is a popular benzodiazepine medication prescribed for an array of conditions including: acute anxiety, alcohol withdrawal, insomnia, panic attacks, restless leg syndrome, and seizures.  Like other benzodiazepines, diazepam functions as a positive allosteric modulator (PAM) of GABAA receptors.  Rather than binding to the same (“A”) subunit of GABAA receptors as the neurotransmitter GABA …

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Anticholinergic Toxicity: Causes, Symptoms, & Treatment

Many drugs have anticholinergic properties, meaning they inhibit the neurotransmission of acetylcholine in the brain.  Drugs with anticholinergic effects prevent acetylcholine from binding to receptors, resulting in therapeutic effects.  There are three major types of anticholinergic drugs including: antimuscarinics, ganglionic inhibitors, and neuromuscular inhibitors – the majority being antimuscarinic. Anticholinergic drugs are often administered for …

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Drug-Induced Psychosis: List Of Causative Agents

Psychosis is a condition that is commonly associated with the mental illness schizophrenia.  It is defined as a detachment from reality and hallmark symptoms include delusions (beliefs that aren’t based in reality) and hallucinations (seeing, hearing, or feeling stimuli that aren’t real).  Those with psychosis are usually admitted to a psychiatric ward and/or hospital and …

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TSPO Ligands For Anxiety: Targeting the Peripheral Benzodiazepine Receptor

Just recently researchers were able to unveil the crystallized structure of translocator protein. It has long been thought that various polymorphisms of the TSPO gene create dysfunctional variations of the translocator protein (18 kDa). The 18 kDa translocator protein is hypothesized to contribute to certain mental illnesses, particularly anxiety disorders. The newly discovered crystallized structure …

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Dementia Linked To Benzodiazepines, Sleeping Pills, Anticholinergics

In recent years, increasing evidence has suggested that certain types of commonly prescribed medications may cause increased risk of developing dementia. This ranges from drugs used to treat anxiety (e.g. Xanax) to over-the-counter drugs (e.g. Benadryl). A majority of these medications tend to depress activity in the CNS and help minimize arousal and/or anxiety. Dementia …

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