MentalHealthDaily

Astrocyte Calcium Signals Shape Amygdala Fear Memory and Extinction in Mice

by GLOOM

Photoreal illustration of astrocytes interacting with neurons in the amygdala, conveying glial role in fear circuit dynamics.

A 2026 Nature mouse study found that basolateral amygdala astrocyte Ca2+ signals tracked fear retrieval and extinction, then showed causality: 3 mg/kg CNO manipulations of astrocyte DREADDs pushed early-extinction freezing in opposite directions while both disrupting later extinction retrieval.1 Research Highlights Astrocytes tracked fear state: after 3 tone-shock pairings and 2 days of 25 cue-only …

D-Cycloserine Targets the NMDA Receptors to Enhance Synpatic Plasticity in Hippocampus (2024 Study)

by GLOOM

In the complex and evolving field of neuroscience, the role of synaptic plasticity in psychiatric disorders has garnered significant attention. d-Cycloserine (DCS), a partial agonist of the N-methyl-D-aspartate receptor (NMDAR), emerges as a key player in potentially revolutionizing treatment approaches. Highlights: d-Cycloserine (DCS): Initially an antimicrobial agent, DCS is now known for its role as …