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CE-123 vs. R-Modafinil for Cognition: Dopamine Modulators (2023 Study)

Recent advancements in neuropharmacology have brought to light S-CE-123, a dopamine transporter inhibitor showing remarkable promise in cognitive enhancement. Its emergence alongside R-modafinil, a well-studied compound with a similar target, paves the way for a fascinating comparative study. This duo of compounds, entwined in the complex dance of brain chemistry, offers a glimpse into the …

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Hydrafinil (Fluorenol): A Modafinil Analogue with Questionable Safety

Hydrafinil (Fluorenol) is an unregulated research chemical originally synthesized by Cephalon Pharmaceuticals (now owned by Teva) as a eugeroic (wakefulness-promoting agent).  After its synthesis, fluorenol was one of several agents to be considered as a hypothetical successor to the popularized and FDA-approved drug, Provigil (Modafinil).  Comparative data from animal trials indicated that fluorenol exhibited ~39% …

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Nuvigil (Armodafinil) vs. Provigil (Modafinil): Comparison

Nuvigil and Provigil are both drugs that were approved by the FDA for the treatment of excessive daytime sleepiness.  Both drugs act as eugeroics and are considered “wakefulness-promoting agents” in that they are distinct from more potent, habit-forming psychostimulants (e.g. Adderall).  Provigil was initially approved in the late 1990s to help treat narcolepsy. Although the drug …

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