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anti-inflammatory

Berberine for Depression: Mechanisms & Antidepressant Effects (2024 Review)

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Depression, a pervasive global health issue, significantly impairs quality of life and burdens the healthcare system. Despite the availability of numerous antidepressants, their effectiveness is often limited, pushing researchers to explore alternative treatments. Berberine, a natural compound with a diverse pharmacological profile, has shown promising antidepressant effects, offering a potential complementary or alternative approach to …

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Mycobacterium vaccae Vaccine: A Novel Soil Bacteria-Based Treatment for Anxiety & Stress Disorders

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Stress can induce anxiety and depression, which appears to be mediated in part by stress-induced neuroinflammatory processes. The immunoregulatory bacterium Mycobacterium vaccae (M. vaccae) has anti-inflammatory and stress-resilient effects, but its impact on the brain is unclear. A study discovered that M. vaccae immunization: induces anti-inflammatory and immunoregulatory processes in the hippocampus, blocks stress-induced neuroinflammation …

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Adjunct Celecoxib for Depression & Mania: Treatment with a COX-2 Inhibitor

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Celecoxib, a selective COX-2 inhibitor, shows promise as an effective and safe adjunct treatment for major depression and mania, according to a new comprehensive systematic review. The analysis also found celecoxib improved symptoms when used as a standalone antidepressant in patients with somatic disorders. However, evidence for efficacy in bipolar depression remains unclear. Key Facts: …

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Minocycline For Depression: Antibiotics As Antidepressants?

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Minocycline is a broad-spectrum antibiotic of the tetracycline classification, indicating that its chemical structure consists of 4 hydrocarbon rings.  The fact that minocycline has a broad-spectrum mechanism indicates that it targets a wide-range of pathogenic (Gram-positive and Gram-negative) bacteria.  In fact, when compared to other tetracycline drugs, minocycline is regarded as having the “broadest spectrum” …

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