Mental Health DailyResearch. Evidence. Perspective.Published research on anhedonia.
In a randomized trial of 111 young adults, one 100-mg dose of amisulpride led to higher blood flow in the ventral striatum than placebo, with or without depression. No other reward region ch…
Read articleMice that only watched another mouse being attacked developed anxiety- and depression-like behavior, but milder and narrower changes than mice that were attacked themselves, according to a 2…
Read articleA 76-person Nature Communications fMRI study found that people with major depressive disorder spent a higher share of time in a model-derived State 3 than healthy controls, 27.63 vs. 25.65, …
Read articleA 2026 preclinical study found that 25C-NBF, a selective 5-HT2A psychedelic phenethylamine, increased plasticity-related markers and produced rapid antidepressant-like effects in male rodent…
Read articleA 244-person functional MRI study found no significant evidence that ventral striatum activation during reward anticipation works as an endophenotype — a measurable trait used to connect inh…
Read articleA 2026 fMRI study of 84 medication-free adolescents found that reward uncertainty had its own phase-specific brain pattern: anxiety, depression, and anhedonia separated across different task…
Read articleAn ear-clip that modulates mood by stimulating the vagus nerve has obvious appeal — but the evidence base for non-invasive tVNS in depression has been mixed for a decade. A 2026 cross-over R…
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