A 2026 analysis of 41 randomized studies involving 21,025 adults with schizophrenia found the largest estimated reductions in hostility and aggression for clozapine (standardized mean difference, or SMD, of −0.75), paliperidone (−0.62), and olanzapine (−0.60) vs. placebo.1 Confidence in every comparison was low or very low, the top 3 were not statistically separable, and most …
A 2026 randomized study involving 80 people with schizophrenia found that adding high-frequency repetitive transcranial magnetic stimulation to risperidone improved PANSS cognitive-factor scores and aggressive-behavior ratings more than risperidone alone over 4 weeks.1 Research Highlights Design was randomized but short: 80 patients were assigned to risperidone alone or risperidone plus rTMS, 40 per group, with …
A 2026 study involving 32 adult mangrove rivulus fish pairs found that 3,000 µg/L waterborne psilocybin reduced movement and aggressive swimming bursts, but the result belongs in animal behavioral pharmacology, not in human aggression treatment claims.1 Research Highlights Fish movement decreased: psilocybin produced a treatment-by-time interaction for time spent moving (p = 0.006), with a …
The complex interplay between the human brain and behavior has long fascinated scientists and laypeople alike, particularly when it comes to understanding the roots of violence. A recent study showcases the hypothalamus, a small but crucial brain region, revealing its significant role in aggression and violent behavior. Highlights: Hypothalamic Volume Reductions Linked to Violence: Studies …
Intermittent explosive disorder (IED) is regarded as a subtype of impulse control disorder characterized by impulsive, uncontrollable explosive outbursts of anger, aggression, and/or rage – sometimes accompanied by violence. To be considered intermittent explosive disorder, the explosive outbursts of anger must be triggered in situations and/or conditions in which such anger is unjustified. In other …