Selective serotonin reuptake inhibitors (SSRIs) are a mainstay in the treatment of various mental disorders but often come with the unwelcome side effect of sexual dysfunction. This issue can significantly affect patients’ adherence to their medication regime, often leading to treatment discontinuation. A recent clinical trial offers a new perspective, suggesting that ‘drug holidays’ – …
The relationship between cannabis (marijuana) use and psychosis has been a topic of considerable scientific interest and public health concern. With changing legal statuses and societal attitudes towards cannabis use in many countries, understanding this relationship is more critical than ever. Highlights: Systematic reviews and meta-analyses show a consistent association between cannabis use and increased …
Narcolepsy, a chronic neurological disorder, significantly impacts the daily lives of those affected due to excessive daytime sleepiness (EDS). Modafinil has been a cornerstone in managing EDS, but its effectiveness can wane over time due to tolerance. An innovative approach, using the drug pitolisant during modafinil ‘drug holidays’, offers new hope for resetting tolerance and …
Depression, a multifaceted mental health disorder affecting millions worldwide, has long been a challenge for both diagnosis and treatment. The standard method for evaluating depression in outpatient settings, the Patient Health Questionnaire-9 (PHQ-9), has traditionally been viewed as a unidimensional tool. However, recent research suggests that the complexities of Major Depressive Disorder (MDD) may be …
Recent research has analyzed the relationship between the use of Anabolic Androgenic Steroids (AAS), sleep quality, and psychological distress. A new study specifically evaluated the effects of anabolic steroids on sleep patterns during both active use and withdrawal phases, among male weightlifters in Norway. Highlights: A large proportion of men using AAS report experiencing sleep …
Generalized Anxiety Disorder (GAD), a prevalent condition among older adults, may be significantly influenced by physical activity levels. Recent research from The Irish Longitudinal Study on Ageing (TILDA) provides groundbreaking insights into how even minimal physical activity can reduce the risk of GAD. Highlights: Minimal Dose for Maximum Benefit: Even low levels of moderate-to-vigorous physical …
Depression, a leading cause of disability globally, often presents challenges in treatment due to the variability in individual responses to antidepressants. Pharmacogenomic (PGx) testing, an approach aligning treatment with genetic makeup, promises to tailor depression therapy more effectively. Highlights: Major Depressive Disorder (MDD) impacts a significant portion of the global population, with traditional treatments often …