A 2026 Cell & Bioscience study found that poly-GR, one of the toxic dipeptide-repeat proteins produced in C9orf72-linked amyotrophic lateral sclerosis (ALS), pushed motor neuron-like cells toward ferroptosis: 4-HNE lipid peroxidation rose at p < 0.0001, labile Fe²+ rose at p < 0.001, and erastin caused more cell death in poly-GR-expressing cells than in control …
A 2026 multi-ancestry genome-wide association study of urinary aMT6s, a melatonin metabolite used as a proxy for overnight melatonin secretion, found 0 genome-wide significant loci in 11,744 people, even though 23 variants reached suggestive significance and 8 were supported by 2 analytic methods. Research Highlights No common variant dominated: the 2026 GWAS meta-analysis involving 11,744 …
A 2026 DIVERGE analysis of 3,677 antidepressant-exposed patients with major depressive disorder in Pakistan classified 34% as treatment resistant, while 86% received psychotropic polypharmacy and only 6% received psychotherapy.1 The CYP2C19 signal is real enough to study prospectively, but the main treatment-system finding is medication stacking in a setting where psychological care was rare. Research …
A 2026 whole-genome sequencing preprint found rare variant signals in 2 multiplex obsessive-compulsive disorder (OCD) families: an NPY5R missense variant in 10 of 15 affected people in 1 pedigree, plus DLGAP1 and MAPK8IP3 signals that tracked all 3 sequenced cases in a branch of a second pedigree.1 The finding is a candidate-gene result, not a …
A 2026 Han Chinese case-control preprint linked the MTHFR C677T variant to schizophrenia with type 2 diabetes: the 677T allele appeared in 81.67% of alleles in the comorbid group vs. 60.00% in controls (p = 0.009), while MTHFR promoter methylation was nearly saturated in both groups (95.00% vs. 90.00%; p = 1.000). Research Highlights Genetic …
A 2026 Singapore birth-cohort preprint found a conditional childhood-anxiety signal: the cord-blood DNA methylation component predicted less age-13 anxiety only in boys in the low DMN-limbic trajectory group from ages 4.5 to 10.5 years. The paper is useful for mapping developmental risk biology, but it is not a screening test and it does not show …
The broad cytokine story failed its most direct community test: in 972 adults, depression, alcohol use, and alcohol use disorder (AUD) were not associated with C-reactive protein (CRP) or a pre-registered pro-inflammatory cytokine index. The only multiple-testing-corrected cytokine hits ran opposite the hypothesis — AUD was linked to lower IL-1β, IL-4, IL-10, and IL-12 — …