MentalHealthDaily

Psilocybin for Major Depression in Adults (2023 Evidence Review)

by GLOOM

The emerging research into psilocybin, a classical psychedelic, reveals its significant potential in treating Major Depressive Disorder (MDD). Historically used in spiritual and shamanic practices, psilocybin’s recent clinical studies have opened new avenues in mental health treatment, challenging traditional antidepressants like SSRIs. Highlights: Psilocybin’s Historical & Clinical Relevance: A natural compound used for millennia, recent …

Customized Transcranial Magnetic Stimulation (TMS) Protocols for Depression & Psychiatric Disorders Based on Personalized Neuroimaging (2023 Evidence)

by GLOOM

Recent advancements in neuroimaging and brain stimulation techniques, particularly Transcranial Magnetic Stimulation (TMS), are revolutionizing the treatment of psychiatric disorders. These technologies, leveraging our understanding of individual brain network architectures, offer the potential for highly personalized treatments. Highlights: Personalization of Treatment: Neuroimaging advancements allow for the personalization of brain stimulation targets, particularly in Transcranial Magnetic …

Genetics of Major Depression vs. Symptom Scales (PHQ-9 & CIDI-SF) (2023 Study)

by GLOOM

Major Depressive Disorder (MDD) presents a significant challenge in mental health, with its complex genetic and symptomatic landscape. Recent research focusing on the UK Biobank data has compared the genetic underpinnings of MDD symptoms assessed by the PHQ-9 and CIDI-SF tools. This comparison has highlighted significant differences in their genetic correlations and implications for understanding …

Esketamine Nasal Spray Effective Last Resort for Treatment-Resistant Depression (TRD)? (2023 Study)

by GLOOM

Treatment-resistant depression (TRD) represents a significant challenge in mental health care, often leaving patients and clinicians in a difficult position after traditional treatments fail. Recent studies, including a prospective, observational study at a leading medical center, have brought new hope in the form of esketamine, a novel antidepressant. Highlights: Esketamine’s Mechanism: Esketamine, the S-enantiomer of …

Analyzing Serum Biomarkers to Predict Antidepressant Efficacy in Depression (2023 Study)

by GLOOM

Depression, a complex and often debilitating mental health condition, affects millions globally. Despite advances in psychiatric medicine, finding the right treatment remains a challenge for many. A recent comprehensive study, however, is shedding light on this issue by examining the role of serum biomarkers in predicting the effectiveness of antidepressant therapy. Highlights: Innovative Approach: This …

Antidepressants & Dementia Risk in Elderly Users: SSRIs vs. TCAs (2024 Study)

by GLOOM

Recent research has uncovered connections between the use of antidepressants and the risk of developing dementia in the elderly. This complex relationship, marked by varying results and considerations, is becoming a critical area of study in geriatric medicine and mental health. In light of these findings, it is crucial to delve into the nuances of …

Non-Directive Supportive Therapy (NDST) for Major Depression: Is It Effective? (2024 Review)

by GLOOM

Depression, a common yet complex mental health disorder, has various treatment options, including psychotherapies like Non-Directive Supportive Therapy (NDST). A recent meta-analysis sheds light on the effectiveness of NDST in treating depression, comparing it with control conditions and other therapies. Highlights: NDST has been identified as a moderately effective treatment for depression compared to control …