A 2026 medRxiv preprint involving 370 healthy adults found that each increase in neighborhood-deprivation percentile rank was associated with epigenetic age acceleration on 3 of 4 second-generation DNA-methylation clocks, with lifetime adversity explaining 20.3% of the GrimAge association and 23.3% of the PCGrimAge association.1 Research Highlights 3 of 4 clocks accelerated: each increase in Area …
A 2026 ABCD cohort preprint involving 10,112 youth found that childhood poverty strengthened the link between cumulative early-life adversity and later behavioral problems; among poverty-exposed youth, inhibitory-control fMRI profiles split children into higher-vulnerability and buffered pathways. Research Highlights Poverty steepened adversity risk: In 10,112 ABCD youth, childhood poverty amplified the baseline early-life-adversity-to-CBCL Total Problems slope …
A 2026 review of 52 studies found that chronic primary pain is linked to several physiological stress markers, especially cortisol, heart rate, heart-rate recovery, and mean arterial pressure. The pattern is real enough to study, but not clean enough to use as a simple biomarker panel for pain severity.1 Research Highlights 52 studies were reviewed: …
A 2026 scoping review screened 174 records and found 7 human studies linking sleep bruxism with gastroesophageal reflux disease.1 The signal was consistent but messy: case-control studies reported roughly 5- to 6-fold higher odds of bruxism with GERD, while instrumental studies suggested reflux episodes, arousals, swallowing, and jaw-muscle bursts may cluster during sleep. Research Highlights …
A 2026 arterial spin labeling MRI study found that 34 patients with non-auditory tinnitus and cerebral venous congestion had lower corrected cerebral blood flow across multiple brain regions than venous-congestion patients without tinnitus and healthy controls.1 Compared with those 2 groups, the tinnitus group had poorer sleep quality, higher depression scores, and slightly lower cognitive …
A 2026 ABCD stop-signal fMRI study found that group-level cognitive-control brain signals often failed to describe within-person brain dynamics: across 16 comparisons, between-person and within-person associations diverged, and several reversed direction.1 The practical warning is narrow but sharp: a brain pattern that separates people in a group may be the wrong map for explaining how …
A 2026 Drosophila Parkinson’s model exposed male and female flies to 500 μM rotenone. By 60 days, male flies had worse survival/climbing than female flies; the paper is a vulnerability screen, not evidence that the same genes are ready human biomarkers.1 Research Highlights 500 μM rotenone split male and female flies: Iyer et al. used …