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Transcranial Magnetic Stimulation (TMS) For Depression: An Effective Treatment?

According to the World Health Organization (WHO), depression is projected to become the number one global disease burden by 2030.  Present-day statistics suggest that depression affects over 350 million people worldwide.  Among those who are depressed, seeking professional psychiatric treatment is often helpful. An estimated 66% of all individuals who seek treatment are able to …

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Nanotechnology For Depression: The Futuristic Potential of Nanopsychiatry

Most pharmacological-based treatments for depression aim to increase levels of various neurotransmitters, particularly serotonin (5-HT).  It is thought that approximately 2 out of 3 individuals that seek treatment with standard antidepressants such as SSRIs and SNRIs are able to attain therapeutic relief.  For a certain percentage of these individuals, the benefits of using pharmaceutical interventions …

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Gene Therapy For Depression: A Futuristic Treatment

Despite the fact that pharmaceutical companies continue to promote the concept of “chemical imbalances” as the root cause of depression, this is a vast oversimplification of an infinitely more complex condition.  While a chemical imbalance may be one of the primary contributing factors to a person’s depression, what causes the chemicals (neurotransmitters) to become imbalanced …

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RNAi For Depression: siRNA Targets SERT & 5-HT1A for Antidepressant Effect

It seems as though society is on the verge of ushering in a new generation of treatment modalities for depression and other psychiatric conditions.  While most people turn to pharmaceutical drugs for major depressive disorder, approximately 1 out of 3 people fail to get sufficient symptomatic relief.  To make matters worse, many end up trying …

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Rexulti (Brexpiprazole) Approved For Schizophrenia & Depression (Adjunct)

Rexulti (Brexpiprazole) is a drug that was approved July 10, 2015 for the treatment of schizophrenia and as an adjunctive option for major depressive disorder.  In clinical trials it was referred to as the chemical “OPC-34712” and is being marketed as a superior successor to Abilify (Aripiprazole) due to the fact that Abilify’s patent expired …

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Spadin (Peptide) For Depression: A TREK-1 Inhibitor Antidepressant

Depression is a growing epidemic that affects the lives of nearly 15 million Americans.  The number of individuals diagnosed with depression will continue to grow as a result of population growth, poor diet, environmental toxins, genetic polymorphisms, and other unique neurophysiological factors.  As a result of depression, it is estimated that nearly 1 out of …

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Antidepressant Trials May Exclude Over 82% of People with Depression

A recent publication in the Journal of Psychiatric Practice documented that nearly 4/5 individuals diagnosed with major depression are considered ineligible to participate in clinical trials for new antidepressant drugs.  This means that for every 5 individuals with depression that attempt to join an antidepressant clinical trial, only one will meet inclusion criteria for registration.  …

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