Mental Health DailyResearch. Evidence. Perspective.Published research on Depression.
A 2026 methylome-wide association study by Shen et al. found 48 CpG methylation sites tied to the quadratic CYP2C19 metabolizer-status term in 18,396 Generation Scotland participants, with 1…
Read articleA 2026 systematic review of subcallosal cingulate (SCC) functional connectivity found 28 qualifying resting-state fMRI studies in depression: 21 rTMS/iTBS studies, 4 ECT studies, 3 focused-u…
Read articleA 2026 two-cohort connectome study found that post-stroke depressive symptoms tracked damage to networks weighted by the serotonin transporter and vesicular acetylcholine transporter: 5-HTT …
Read articleA 2026 retrospective case series of 22 adults with treatment-resistant depression and comorbid PTSD found that trauma re-experiencing during intranasal esketamine disappeared over later sess…
Read articleParenteral clomipramine has a strong clinical myth around it: bypass the gut, raise parent-drug exposure quickly, and maybe accelerate rescue in severe depression or OCD. A 2026 systematic r…
Read articleA 2026 fMRI meta-analysis of 11 studies found a narrow anxious-depression signal: 829 anxious-depression patients differed from 681 non-anxious MDD patients in left middle temporal gyrus act…
Read articleA 2026 meta-analysis of 56 controlled trials found the clearest gamma-frequency neuromodulation signal in schizophrenia: overall symptoms improved vs. control (g = −0.46), global cognition i…
Read article
