Mental Health DailyResearch. Evidence. Perspective.Published research on Depression.
A 2026 resting-state fMRI study of 800 adults found intra-thalamic hypoconnectivity across schizophrenia, bipolar disorder, and major depression, but schizophrenia showed far broader subcort…
Read articleA 2026 PRONIA preprint involving 727 discovery-sample participants found that early mental illness severity cut across psychosis risk, recent psychosis, and recent depression: groups with hi…
Read articleA 25-person pilot study of young adults found an ATP fatigue pattern that was directionally reversed from the simple “low brain energy” story: the depression group had higher visual-cortex A…
Read articleA 2026 medRxiv preprint reported that an at-home subcallosal cingulate cortex deep brain stimulation (SCC DBS) recording system could track stable recovery in severe treatment-resistant depr…
Read articleA 2026 randomized trial in early postmenopausal women found that 8 weeks of app-based combined aerobic and resistance exercise reduced Beck Depression Inventory scores by 7.30 points, compar…
Read articleA 2026 NHANES mortality analysis found that adults with PHQ-9 depressive symptoms had lower long-term all-cause mortality when their CALLY index was higher: in the fully adjusted model, each…
Read articleA 2026 DIVERGE analysis of 3,677 antidepressant-exposed patients with major depressive disorder in Pakistan classified 34% as treatment resistant, while 86% received psychotropic polypharmac…
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