Mental Health DailyResearch. Evidence. Perspective.Published research on antidepressants.
A 2026 ANTLER mechanistic analysis found no evidence that maintaining antidepressants preserved a happier facial-emotion recognition pattern compared with placebo substitution at 12 weeks (a…
Read articleA 2026 Environmental Science & Technology experiment found that wild guppies still reduced maze solve times with practice after 11-day exposure to environmentally motivated amitriptyline con…
Read articleA 913-person economic evaluation of the PReDicT antidepressant algorithm found nearly identical EQ-5D quality-of-life gains vs. treatment as usual (+0.139 vs. +0.140) and nearly identical so…
Read articleA 124-person study of euthymic bipolar disorder found that patients with early systematic antidepressant treatment history had higher negative affect, attentional impulsivity, non-planning i…
Read articleMajor upper-extremity amputation was linked to substantially higher odds of new mental-health diagnosis, antidepressant initiation, and psychotherapy claims than minor upper-extremity amputa…
Read articleA 2026 DIVERGE analysis of 3,677 antidepressant-exposed patients with major depressive disorder in Pakistan classified 34% as treatment resistant, while 86% received psychotropic polypharmac…
Read articleA 2026 clinical-lab study tested a 77-drug liquid chromatography-tandem mass spectrometry serum screen in 1,021 patients and found that benzodiazepines accounted for 37.9% of all detections,…
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