A 2026 ANTLER mechanistic analysis found no evidence that maintaining antidepressants preserved a happier facial-emotion recognition pattern compared with placebo substitution at 12 weeks (adjusted mean difference 0.23, 95% CI −0.5 to 1.0, p = 0.5) or 52 weeks (0.29, 95% CI −0.5 to 1.2, p = 0.5). Research Highlights No 12-week maintenance advantage: discontinuation …
A 2026 Environmental Science & Technology experiment found that wild guppies still reduced maze solve times with practice after 11-day exposure to environmentally motivated amitriptyline concentrations, but exposed males made 26.35% to 34.21% more navigation errors than control males.1 The result is a sex-specific accuracy signal, not a blanket claim that antidepressant pollution erased learning. …
A 913-person economic evaluation of the PReDicT antidepressant algorithm found nearly identical EQ-5D quality-of-life gains vs. treatment as usual (+0.139 vs. +0.140) and nearly identical societal cost reductions (−€2,589 vs. −€2,602), while cost-effectiveness probabilities were only 46% to 59% at trial level but exceeded 80% in the UK.1 The algorithm signal was country-specific and capability-weighted, …
A 124-person study of euthymic bipolar disorder found that patients with early systematic antidepressant treatment history had higher negative affect, attentional impulsivity, non-planning impulsivity, and total BIS-11A impulsivity scores than matched patients without that history.1 The association is clinically cautionary, but the cross-sectional design cannot separate antidepressant effects from delayed bipolar diagnosis or more severe …
Major upper-extremity amputation was linked to substantially higher odds of new mental-health diagnosis, antidepressant initiation, and psychotherapy claims than minor upper-extremity amputation in a matched national database study. The clearest clinical implication is early mental-health screening after major limb loss, not waiting for distress to surface months later.1 Research Highlights 2,452 matched patients were analyzed: …
A 2026 DIVERGE analysis of 3,677 antidepressant-exposed patients with major depressive disorder in Pakistan classified 34% as treatment resistant, while 86% received psychotropic polypharmacy and only 6% received psychotherapy.1 The CYP2C19 signal is real enough to study prospectively, but the main treatment-system finding is medication stacking in a setting where psychological care was rare. Research …
A 2026 clinical-lab study tested a 77-drug liquid chromatography-tandem mass spectrometry serum screen in 1,021 patients and found that benzodiazepines accounted for 37.9% of all detections, ahead of antidepressants and antipsychotics.1 Emergency-department cases were a small slice of the sample, but they were positive more often than outpatients: 85.2% vs. 59.5%. Research Highlights Benzodiazepines dominated …