A 2026 SEEearly baseline report found that 53.3% of 184 young people with early schizophrenia-spectrum psychosis were not in employment, education, or training at study entry, even though 97.8% had at least a lower- or upper-secondary school-leaving qualification.1 Psychosis had already interrupted the bridge from school into training, college, or competitive work. Research Highlights NEET …
A 2026 PRO-ACT analysis of amyotrophic lateral sclerosis (ALS) trial data found a signal that ordinary ALSFRS total-score slopes cannot even express: Shannon entropy trajectories diverged between pooled active and placebo arms, including a 5-month delay in peak Fine Motor distributional spread for active-arm patients.1 Research Highlights Entropy found an endpoint-level signal: Rodriguez analyzed 7,512 …
A 2026 individual participant data meta-analysis of 1,721 dementia trial participants linked risperidone to cerebrovascular adverse events, HR 4.11 (95% CI 1.77 to 9.51), and major cardiovascular adverse events, HR 2.00 (95% CI 1.23 to 3.26).1 The timing signal is the practical warning: median first cerebrovascular event appeared at 4.3 weeks, and median first major …
A 2026 immunopsychiatry cohort study found that soluble CD27 (sCD27), a marker of T-cell activation, was positive in cerebrospinal fluid in 23% of severe psychiatric patients selected for suspected immune involvement and in 88% of multiple sclerosis patients used as a positive-control group. In the psychiatric cohort, combined cerebrospinal fluid or blood sCD27 positivity was …
A 2026 Saudi tertiary-hospital study estimated that adults treated for fibromyalgia — chronic widespread pain with fatigue, sleep disruption, cognitive symptoms, and overlapping mood or medical problems — generated SAR 9,601.2 (USD 2,560.3) in annual direct medical costs per patient, with specialist visits and diagnostic procedures accounting for 96.3% of recorded spending.1 Research Highlights Annual …
A 2026 psychometric study of 354 Swedish participants found that 1-week versions of the PHQ-15 and SSD-12 mostly preserved internal consistency and construct validity, but reliability was acceptable mainly in clinical participants or when researchers averaged 2 timepoints. Research Highlights Clinical tracking looked more defensible than healthy screening: Hybelius et al. studied 194 people with …
A 2026 ABCD Study preprint involving 11,868 youth found stable time-ordered predictors of teen substance-use initiation, but the adjusted effects were small: most estimates ranged from −0.01 to 0.02 initiation-probability points per 1-SD predictor increase. Research Highlights Large ABCD panel: Wei et al. analyzed 11,868 youth with repeated observations and interval-level initiation outcomes for alcohol, …