A 2026 review concluded that GLP-1 receptor agonists have plausible stroke biology and modest prevention signals, but current human evidence does not support routine use as acute ischemic stroke neuroprotection.1 The useful clinical split is prevention in cardiometabolic patients vs. acute brain-rescue treatment after stroke onset. Research Highlights Acute neuroprotection is not established: the 2026 …
A 5-year PPMI cohort analysis found that lower serum uric acid independently predicted incident depression in prodromal Parkinson’s disease (HR = 0.776; 95% CI 0.619-0.974; P = 0.029).1 The signal sits beside a lower-p-value non-motor symptom predictor: higher MDS-UPDRS Part I scores also predicted depression (HR = 1.177; 95% CI 1.093-1.267; P < 0.001). Research ...
A 2026 rat study found that activating PACAP signaling in the lateral septum amplified stress-hormone release and anxiety-like behavior, while blocking endogenous PACAP receptors produced an anxiolytic pattern.1 The result makes the lateral septum look less like a passive relay and more like a stress-reactivity node in the PACAP pathway. Research Highlights Stress hormones rose: …
A 2026 PLOS One computational study linked Trichostatin A to 949 predicted targets and 8 machine-learning-selected Alzheimer’s disease core genes, but 100 ns molecular dynamics simulations suggested the compound did not stably bind those candidate proteins.1 That makes the result more useful as an epigenetic network hypothesis than as evidence for a near-term Alzheimer’s drug. …
A 2026 Spanish Rett Syndrome Behavior Questionnaire validation preprint found strong test-retest reliability across 51 caregivers, including an intraclass correlation coefficient of 0.907 and a 31-person short-interval subset with Pearson r2 = 0.8663.1 The result supports Spanish-language research access, but it is linguistic validation rather than proof that the scale diagnoses Rett syndrome or measures …
A 2026 study of 250 mothers of children with intellectual and developmental disabilities (IDDs) found that family burden was strongly tied to lower social support, lower family quality of life, and lower happiness. In the structural model, the burden-happiness link was explained by perceived support and family quality of life rather than a direct burden-to-happiness …
A self-localized ultrafast pencil beam is not a brain treatment, but it could become useful imaging infrastructure for neuroscience and drug-delivery research. In an arXiv preprint, Cao et al. generated a stable ultrafast beam inside a standard multimode fiber and used it for volumetric multiphoton imaging of intact mouse enteric nervous tissue and a live …