A Global Burden of Disease analysis estimated that U.S. age-standardized substance-use disorder disability-adjusted life-year rates rose 213.5% from 1990 to 2019, with opioid use disorders producing the steepest increase and the largest state-level burden.1 Research Highlights U.S. cases rose sharply: prevalent substance-use disorder cases increased from 12.6 million in 1990 to 19.5 million in 2019.1 …
A 2026 review argued that G protein-coupled receptor 30 may connect estrogen signaling, trigeminal pain pathways, and migraine biology, but migraine-specific human trials of GPR30-targeted drugs are still missing. Research Highlights The migraine rationale is hormone-linked: women have roughly 2 to 3 times the migraine prevalence of men, and 50% to 60% of women with …
A 2026 mouse and cell study found that ATP11B loss pushed aged brains toward hippocampal iron accumulation, mitochondrial dysfunction, neuronal ferroptosis, and worse memory behavior than wild-type comparison mice; ATP11B overexpression then improved multiple learning and memory tests in 18-month-old mice. Research Highlights Memory signal: ATP11B-deficient mice performed worse than wild-type mice on Morris water …
A 2026 medRxiv preprint used 68 NeuroMark SPECT components to analyze 2,746 psychiatric patient scans and 76 controls, linking depression-related worry/rumination and social disinterest to brain-network patterns.1 This preprint is useful as a large biomarker-generating map, but the clinical-diagnostic claim needs much more caution than the sample size alone suggests. Research Highlights Large clinical SPECT …
A 2026 PLOS One study fine-tuned Qwen-2.5 and GLM-4 for psychology questionnaire generation and reported the largest gain in readability and comprehension difficulty: 3.41 to 4.66 on a 0–5 scale, a 36.7% relative improvement.1 The result supports item drafting inside a psychometric workflow, while clinical or research scale use still requires ordinary validation. Research Highlights …
A 2026 medRxiv preprint found that REDDI, a resting-state magnetoencephalography machine-learning pipeline, separated mild cognitive impairment, multiple sclerosis, Parkinson’s disease, and amyotrophic lateral sclerosis with 0.81 ± 0.04 balanced accuracy across 5 folds.1 That is a meaningful jump over the prior 67.1% MEG benchmark, but it is still research-stage decision support rather than a clinical …
A 2026 Parkinsonism study involving 63 male rats found that Antrodia cinnamomea plus citrate-stabilized silver nanoparticles reduced 6-OHDA motor, oxidative-stress, inflammatory, α-synuclein, and apoptosis markers, while dopamine and acetylcholine recovery remained nonsignificant. The useful claim is a multitarget preclinical signal, not a Parkinson’s disease treatment recommendation. Research Highlights Combination treatment looked strongest: Tekiner et al. …