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type 2 diabetes

SMART Texts Raised Diabetes Confidence in Schizophrenia

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MHD featured image for SMART text messages and diabetes self-management in schizophrenia.

A 12-week text-message intervention for people with schizophrenia spectrum disorders improved diabetes self-management confidence and patient activation, but it did not yet move weight, HbA1c, physical activity, or psychiatric symptoms. SMART looked feasible and psychologically useful in this uncontrolled pilot; cardiometabolic outcomes need a full-scale randomized trial with longer follow-up.1 Research Highlights SMART was tested …

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Melatonin aMT6s GWAS Found No Hits, PRS Linked to Sleep and Diabetes

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MHD featured image for melatonin metabolite genetics, sleep duration, and type 2 diabetes signals.

A 2026 multi-ancestry genome-wide association study of urinary aMT6s, a melatonin metabolite used as a proxy for overnight melatonin secretion, found 0 genome-wide significant loci in 11,744 people, even though 23 variants reached suggestive significance and 8 were supported by 2 analytic methods. Research Highlights No common variant dominated: the 2026 GWAS meta-analysis involving 11,744 …

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MTHFR C677T Linked to Schizophrenia With Type 2 Diabetes in Han Chinese

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Editorial card showing MTHFR genetics, folate metabolism, schizophrenia, and type 2 diabetes signals in a Han Chinese cohort.

A 2026 Han Chinese case-control preprint linked the MTHFR C677T variant to schizophrenia with type 2 diabetes: the 677T allele appeared in 81.67% of alleles in the comorbid group vs. 60.00% in controls (p = 0.009), while MTHFR promoter methylation was nearly saturated in both groups (95.00% vs. 90.00%; p = 1.000). Research Highlights Genetic …

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