MentalHealthDaily

Parkinson’s Diabetes Oxidative Stress: 8-OHdG Rose, F2-Isoprostanes Did Not

by GLOOM

MHD featured image for Parkinson's disease, diabetes, oxidative stress, 8-OHdG, and F2-isoprostanes.

A 2026 meta-analysis of 54 human studies found that 8-hydroxy-2′-deoxyguanosine rose in Parkinson’s disease, while F2-isoprostanes did not show a statistically confirmed Parkinson’s signal; type 2 diabetes showed much larger peripheral oxidative-stress elevations than Parkinson’s disease for both biomarkers. Research Highlights Parkinson’s DNA-oxidation signal was moderate: Msigwa et al. pooled 5 Parkinson’s disease studies with …

Post-Meal Glucose Genetics Linked to Lacunar Stroke Risk

by GLOOM

MHD featured image for post-meal glucose genetics and lacunar stroke risk.

A 2026 medRxiv genetic analysis linked type 2 diabetes and 2-hour postprandial glucose — the blood-sugar rise after an oral glucose challenge — to higher lacunar stroke risk, with a stronger direct signal for post-meal glucose than for HbA1c after adjustment for brain small-vessel imaging markers.1 Research Highlights Lacunar stroke was the clearest endpoint: genetically …

Semaglutide Did Not Increase Suicidality in 102,361 Veterans

by GLOOM

MHD featured image for semaglutide and suicidality risk in veterans with type 2 diabetes.

A 2026 target-trial emulation involving 102,361 U.S. veterans with type 2 diabetes found no increased suicidality risk after starting semaglutide vs. sodium-glucose cotransporter-2 inhibitors (SGLT2 inhibitors): suicidal ideation HR 0.99 and suicide attempt/death HR 1.05 after overlap weighting.1 That does not prove semaglutide prevents suicide, but it weakens the broad claim that semaglutide initiation itself …

SMART Texts Raised Diabetes Confidence in Schizophrenia

by GLOOM

MHD featured image for SMART text messages and diabetes self-management in schizophrenia.

A 12-week text-message intervention for people with schizophrenia spectrum disorders improved diabetes self-management confidence and patient activation, but it did not yet move weight, HbA1c, physical activity, or psychiatric symptoms. SMART looked feasible and psychologically useful in this uncontrolled pilot; cardiometabolic outcomes need a full-scale randomized trial with longer follow-up.1 Research Highlights SMART was tested …

Melatonin aMT6s GWAS Found No Hits, PRS Linked to Sleep and Diabetes

by GLOOM

MHD featured image for melatonin metabolite genetics, sleep duration, and type 2 diabetes signals.

A 2026 multi-ancestry genome-wide association study of urinary aMT6s, a melatonin metabolite used as a proxy for overnight melatonin secretion, found 0 genome-wide significant loci in 11,744 people, even though 23 variants reached suggestive significance and 8 were supported by 2 analytic methods. Research Highlights No common variant dominated: the 2026 GWAS meta-analysis involving 11,744 …

Progressive Muscle Relaxation Reduced Diabetes Fatigue, Not Sleep

by GLOOM

MHD featured image for progressive muscle relaxation, diabetes fatigue, and sleep quality.

A 2026 randomized trial in 63 adults with type 2 diabetes found that progressive muscle relaxation was linked to a large fatigue drop in the intervention group, from a Fatigue Severity Scale mean of 51.58 to 34.12, but adjusted between-group tests did not confirm a clear advantage over control for fatigue or sleep quality.1 The …

MTHFR C677T Linked to Schizophrenia With Type 2 Diabetes in Han Chinese

by GLOOM

Editorial card showing MTHFR genetics, folate metabolism, schizophrenia, and type 2 diabetes signals in a Han Chinese cohort.

A 2026 Han Chinese case-control preprint linked the MTHFR C677T variant to schizophrenia with type 2 diabetes: the 677T allele appeared in 81.67% of alleles in the comorbid group vs. 60.00% in controls (p = 0.009), while MTHFR promoter methylation was nearly saturated in both groups (95.00% vs. 90.00%; p = 1.000). Research Highlights Genetic …