Cognitive impairment in first-episode schizophrenia (FES) is the symptom that does the most work blocking employment, relationships, and independent living — and the symptom current antipsychotics barely move. A 2026 RCT by Hu et al. in Psychological Medicine tested whether 20 sessions of low-frequency rTMS targeting the right orbitofrontal cortex (OFC) could improve cognition where …
A 2026 systematic review of subcallosal cingulate (SCC) functional connectivity found 28 qualifying resting-state fMRI studies in depression: 21 rTMS/iTBS studies, 4 ECT studies, 3 focused-ultrasound studies, and 0 DBS or tDCS studies.1 That number is the useful correction: SCC DBS may still be biologically plausible, but the current fMRI connectivity literature mostly explains noninvasive …
Repetitive transcranial magnetic stimulation (rTMS) is making waves in the field of Alzheimer’s disease (AD) research, offering a glimmer of hope for enhancing cognitive functions in patients. By targeting specific brain regions, rTMS has shown promising results in modulating neural activity and improving cognitive scores. This innovative therapy, coupled with real-time monitoring through electroencephalography (EEG), …
Depression, a common yet severe mood disorder, affects millions worldwide, posing significant challenges in both diagnosis and treatment. Recent advancements have led to the development of accelerated transcranial magnetic stimulation (aTMS), a novel approach aiming to offer rapid relief for individuals suffering from major depressive disorder (MDD). This revolutionary technique has shown promising results, potentially …
Major depressive disorder (MDD) is a critical public health issue, particularly due to the high risk of suicide associated with it. Traditional treatments often take weeks to show effects and sometimes increase suicide risk in the early phases of therapy. However, a new approach, the Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT), is showing promise in …
TMS (Transcranial magnetic stimulation) is considered a non-invasive neurostimulation procedure aimed at normalizing brain activity among those with abnormal neurological function. Individuals diagnosed with psychiatric conditions (e.g. depression) may turn to TMS for relief if standard first-line pharmacological options fail to ameliorate symptoms. A TMS device works by using pulsed magnetic fields to generate low-grade electrical currents. …