Psilocybin for Depression, MDMA for PTSD: What Phase 3 Trials Show
Media coverage of psychedelics outpaces the trial evidence. MDMA-PTSD signals are large; psilocybin-depression effects shrink against active comparators.
depression
How Much Does Loneliness Raise Dementia and Suicide Risk?
Loneliness raises measured risk of Alzheimer’s, suicidal ideation, and completed suicide. The associations are documented; the precise magnitudes are not.
When Inflammation Drives Depression — and When It Doesn’t
‘Depression is inflammation’ holds for a subgroup of patients, not for everyone. Community-sample and twin data weaken the broader version of the claim.
Exercise for Depression and Anxiety: 2025 Evidence Synthesis
Exercise reliably reduces depression and anxiety symptoms — but the cardio-vs-resistance gap and antidepressant parity claims are overstated.
Sex Differences of Gut Bacteria (Microbiome) in Major Depression (2024 Review)
The intricate relationship between the gut microbiome and major depressive disorder (MDD) is gaining significant attention within the scientific community. Emerging research highlights sex-specific disparities in the gut microbiome’s composition and its potential impact on MDD, pointing towards the necessity of integrating sex as a biological variable in future studies. Highlights: Sex Disparities in MDD: …
Genetics of Major Depression Linked to Increased Risk of Obstructive Sleep Apnea (OSA) (2024 Study)
In a new study leveraging Mendelian Randomization, researchers highlight the complex interplay between psychiatric disorders, specifically major depressive disorder (MDD), and obstructive sleep apnea (OSA). This meticulous investigation sheds light on the genetic predispositions that suggest a causal relationship between MDD and increased risk of developing OSA, offering new insights into the bidirectional interconnections of …
Hikikomori & Loneliness in Japan: Trends, Definitions, Demographics (2024 Report)
In Japan, a country facing unique demographic challenges, loneliness has emerged as a pressing public health issue, intricately linked with the phenomenon known as hikikomori, or extreme social withdrawal. Through a detailed analysis of a nationwide survey and various factors influencing loneliness, a new study sheds light on the complexity of social isolation in modern …